Assistant Professor, Department connected with Pharmacology & Toxicology
Education/Training: Ph.D.: University associated with Toronto, Toronto, Ontario, Canada (2000) Postdoctoral Fellowship: University associated with California at Los Angeles, CA, USA (2003) Scientific Associate: Toronto Western Research Institute, Toronto, Ontario, Canada (2007)
CRMPs, novel government bodies with calcium homeostasis within well being along with disease.
My laboratory is trying to better realize the molecular as well as mechanistic groundwork from the functions connected with ion channels inside human wellness and also disease. In particular, my laboratory s homework is designed in order to examine basic principles involving synaptic transmission simply because improper functionality as well as regularions of Ca2+ programmes as well as proteins that will get a grip on these can develop epilepsy, migraine, ataxia, and also other neurological diseases. Three jobs tend to be at present currently being pursued inside my laboratory:
In the first project, funded because of the American Heart Association National Scientist Development grant, we certainly have aimed with studying that effects connected with collapsin response mediator protein 2 (CRMP-2), a family group with proteins involved in neurite outgrowth, guidance, and also axonogenesis about voltage-gated calcium (Cav2.2) channels. Our main objective is usually to recognize the practical consequence of the novel interaction in between these types of presynaptic Ca2+ options plus CRMPs with synaptic transmission. As modifying transmitter generate is important in altering neuronal characteristics during development, learning, sickness states, as well as other types connected with neural plasticity, each of our upcoming research could examine exactly how this particular discussion can easily help with mastering as well as memory.
In the second project, funded from the Department of Defense Neurofibromatosis New Investigator Award, we're taking care of your novel pathway with regard to Neurofibromatosis type I (NF1), a great autosomally major ailments known by the development of multiple harmless and cancerous tumors. People with NF1 usually have studying disabilities and also other cognitive symptoms. Our scientific studies have diagnosed a completely new pathway with regard to NF1 signaling. This novel pathway involves an axonal guidance and growing protein known as CRMP-2 which usually may be demonstrated for you to purpose in neuronal differentiation. The convergence regarding signaling pathways of CRMP-2 along with NF1 has diagnosed various molecular players, kinases in particular, in which have an impact on neuronal function. Our book breakthrough discovery in the CRMP-2 Ca2+ sales channel discussion and also the NF1-CRMP-2 discussion streaks a story regulator connected with synaptic transmission. Manipulation of glutamatergic tranny might thus stand for a specialized method regarding NF1 therapy. Thus, the particular offered mapping of the NF1 CRMP-2 discussion may well lead to your identification of peptides capable associated with keeping the actual modulatory effects on this protein complex on synaptic transmission.
In another project, we certainly have focused on defining what sort of period levels associated with CRMP-2 can have an impact on the results on the novel anticonvulsant meds lacosamide about Na+ channels. Lacosamide can be a new book anticonvulsant narcotic that behaviors in a unique manner to help inhibit voltage-gated Na+ avenues because described continue year. Lacosamide offers received FDA and EEMA approval intended for adjunctive remedies pertaining to partial-onset seizures with or maybe with out secondary generalization throughout sufferers with epilepsy and it is right now sold throughout this United States plus Europe. In preclinical findings reported by UCB Pharma, another focus on regarding activity ended up being recognized for this drug. The instrument of action of lacosamide upon this specific second target the particular collapsin reaction mediator protein only two (CRMP-2) remains elusive. No reports to go out with include addressed your benefits of the likely interaction to the main effect with lacosamide.
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